application of 1,3-dipolar reagents in organic synthesis, synthesis and modification of triazoles, pyrazoles and other heterocycles, pharmaceutical chemistry, bioactive molecules, computational chemistry, fine organic synthesis, green chemistry.

Research papers: 

1. Pokhodylo N.,  Finiuk N., KlyuchivskaO., Тupychak M., Matiychuk V., Goreshnik E., Stoika R. Novel N-(4-thiocyanatophenyl)-1H-1,2,3-triazole-4-carboxamides exhibit selective cytotoxic activity at nanomolar doses towards human leukemic T-cells. European Journal of Medicinal Chemistry. 2022. Vol. 241. 114633. https://doi.org/10.1016/j.ejmech.2022.114633
2. Slyvka Y., Goreshnik E., Pokhodylo N., Morozov D., Tupychak M., Mys’kiv M. Allylcytisine as a convenient scaffold for the construction of the π, σ-coordination compound {Acyt (H⁺)}[Cu₈{Acyt(H⁺)}Cl₁₀] with the unusual anionic 1D-coordination polymer. Polyhedron. 2022. Vol. 224. 116022. https://doi.org/10.1016/j.poly.2022.116022
3. Tupychak M. A., Finiuk N. S., Stoika R. S., Martyak R. L., Pokhodylo N. T. Design, synthesis and in vitro anticancer activity of benzo[c]chromen-6-one-linked 1,2,3-triazole. Lett. Drug Des. Discov. 2022. Vol.19, Iss. 6, P. 490–499.  DOI: https://doi.org/10.2174/1570180819666220124112740
4. Tupychak M. А., Obushak M. D. New methods for the synthesis of substituted 4,5,6,7-tetrahydro[1,2, 3]triazolo[1,5-a]pyrazines (microreview). Chem. Heterocycl. Compd. 2021. Vol.57. P. 1164–1166. DOI: https://doi.org/10.1007/s10593-021-03037-8 .
5. Shyyka O., Svyrydenko M., Tupychak M., Pokhodylo N., Obushak M.  Synthesis of novel 3-(1,2,4-oxadiazol-5-yl)thiophen-2-amine derivatives via Gewald reaction // Visnyk of the Lviv University. Series Chemistry. 2021. Iss. 62. P. 183–190.  https://doi.org/10.30970/vch.6201.183
6. Tupychak M. А., Pokhodylo N. T., Obushak M. D. Dialkyl (2-oxopropyl)phosphonates in the synthesis of phosphorylated heterocycles // Heterocycl. Compd.  – 2020. – Vol. 56, Iss. 12. – P. 1125–1129. https://doi.org/10.1007/s10593-020-02786-2
7. Pokhodylo N. T., Tupychak M. A., Palchykov V. A. Dihydro-2H-thiopyran-3(4H)-one-1,1-dioxide – a new cyclic ketomethylenic reagent for the Dimroth-type 1,2,3-triazole synthesis // Synth. Commun. – 2020. – Vol. 50, No. 12. – P. 1835-1844. https://doi.org/10.1080/00397911.2020.1757113
8. Tupychak M. A., Shyyka O. Ya., Pokhodylo N. T., Obushak M. D. Nitrileimines as an alternative to azides in base-mediated click [3+2]cycloaddition with methylene active nitriles // RSC Adv. – 2020. – Vol. 10. – P. 13696-13699. https://doi.org/10.1039/d0ra01417f
9. Pokhodylo N. T., Shyyka O. Ya., Tupychak M. A., Slyvka Yu. I., Obushak M. D. Concurrent pathway and unexpected products in the CuAAC reaction of ethyl prop-2-ynyl methylphosphonate with aromatic azides // Chem. Heterocycl. Compd. – 2019. – Vol. 55, 4/5. – P. 374-378. https://doi.org/10.1007/s10593-019-02467-9
10. Pokhodylo N. T., Shyyka O. Ya, Tupychak M. A., Obushak M. D. Selectivity in domino-reaction of ortho-carbonyl azides with malononitrile dimer leading to [1,2,3]triazolo[1,5-a]pyrimidines // Chem. Heterocycl. Compd. – 2018. – Vol. 54, 2. – P. 209-212. https://doi.org/10.1007/s10593-018-2256-4
11. Shyyka O. Ya., Martyak R. L., Tupychak M. A., Pokhodylo N. T., Obushak M. D. Facile synthetic route to benzo[c]chromenones and thieno[2,3-c]chromenones // Synth. Commun. − 2017. – Vol. 47, No. 24. – P. 2399-2405. https://doi.org/10.1080/00397911.2017.1380833

Conference presentations:

1. Pokhodylo N. (oral, video presentation) New carbazole-π-bridge-triazole compounds for OLED applications / Pokhodylo, R. Lytvyn, M. Stanicka, M. Tupychak, Kh. Pitkovych, O. Bezvikonnyi, E. Urbonas, D. Volyniuk, S. Kutsiy, K. Ivaniuk, V. Kinzhybalo, P. Stakhira, A. Tomkeviciene, J.V. Gražulevičius, M. Obushak // 12-th International Conference “Electronic Processes in Organic and Inorganic Materials” (June 1-5, 2020). – Kamianets-Podіlskyi, 2020. – s6-045
2. Pokhodylo N., Lytvyn R., Stanicka M., Tupychak M., Pitkovych Kh., Bezvikonnyi, Urbonas O. E., Volyniuk D., Kutsiy S., Ivaniuk K., Kinzhybalo V., Stakhira P., Gražulevičius J. V., Obushak M. Design, synthesis and studies of carbazole and triazole based materials for oled applications // Матер. Ювілейної ХХV Укр. конф. з органічної та біоорганічної хімії – Луцьк, 2019. – C. ПД-6.
3. Pokhodylo N., Shyyka О., Tupychak M., Obushak M. The unpredicted courses and unexpected products in the reaction of azides with alkynes (CuAAC) or methylene ketones // Book Abs. 8 Int. Conf. “Chemistry of nitrogen containing heterocycles” in memoriam of Prof. Valeriy Orlov – Kharkiv, 2018. – P. 39.
4. Tupychak M. A., Shyyka O. Ya., Pokhodylo N. T., Obushak M. D. Synthesis of new heterocyclic compounds with both thiophene and 1,2,4-triazole scaffolds // 7 Int. Youth Science Forum “Litteris et artibus” – Lviv, 2017. – P. 56-57.
5. Shyyka O. Ya, Pokhodylo N. T., Tupychak M. A., Matiychuk V. S., Obushak M. D. Anticancer activity evaluation of new thienopyrimidine derivatives // Coll. IX Int. Conf. Chemistry. Kyiv-Toulouse – Kyiv, 2017. – P. 106.

Was born in Bahnuvate, Turka district, Lviv region.

2018 – graduated from the Faculty of Chemistry of Ivan Franko National University of Lviv.

2018–2022 – studied at the postgraduate course of the Department of Organic Chemistry of Ivan Franko National University of Lviv.

2022 – defended dissertation for the scientific degree of Doctor of Philosophy, specialty 102 ‒ Chemistry (topic “1,3-Dipolar reagents in the synthesis of azoles”).

2022–2023 – lecturer at the Department of Organic Chemistry of Ivan Franko National University of Lviv.

2023-till now – associate professor at the Department of Organic Chemistry of Ivan Franko National University of Lviv.

2020     Gratitude of the Ministry of Education and Science of Ukraine.
2020     The academic scholarship of the Cabinet of Ministers of Ukraine for PhD student.
2019      Award of Lviv Regional State Administration and Lviv regional council for young scientists and researchers
2018     winner of the scholarship program competition “Zavtra. UA” of the Victor Pinchuk Foundation
2018     The Ukrainian Students Chemistry Olympiad, I place
2016     The Ukrainian competition of student research works on natural, technical and humanitarian sciences in the 2015/2016 academic year, direction – Chemical Science, I place
2015     Award of Lviv Regional State Administration and Lviv regional council

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