• Research of chemical properties of quinoid compounds;
• Heterocyclic compounds;
• Pyrrole derivatives;
• Synthetic application of Meerwein reaction products in the synthesis of heterocycles of different classes.

• Chemistry of Life
• Pharmaceutical Chemistry and Pharmacology
• Toxicological Chemistry and Ecotoxicology

Selected articles

1. Pokhodylo N. The (1H-Tetrazol-1-yl)arenediazonium salts as convenient reagents for quinones arylation: synthesis of 1,3-benzoxathiol-2-ones and naphtho[2,1-d][1,3]oxathiol-2-ones bearing (1H-tetrazol-1-yl)phenyl motif / N. Pokhodylo, R. Martyak, M. Тupychak, Kh. Pitkovych, V. Matiychuk, M. Obushak // Chem. Chem. Technol. – 2023. – Vol. 17. No. 2. – P. 304–314. (https://doi.org/10.23939/chcht17.02.304)
2. Tupychak M.A. Design, synthesis and in vitro anticancer activity of benzo[c]chromen-6-one linked 1,2,3-triazole / M.A. Tupychak, N.S. Finiuk, R.S. Stoika, R.L. Martyak, N.T. Pokhodylo // Lett. Drug Des. Discov. – 2022. – Vol. 19. No 6. – P. 490–499. http://DOI: 10.2174/1570180819666220124112740
3. Matiichuk Y. Synthesis, antimicrobial and anticancer activities of 1-aryl-4-[(5-aryl-2-furyl)carbonothioyl]piperazines / Y. Matiichuk, A. Grozav, L. Kostyshyn, N. Yakovychuk, T. Chaban, R. Martyak, V. Matiychuk // Biointerface Res. Appl. Chem. – 2022. – Vol. 12. No 1. – P. 706–717. https://doi.org/10.33263/BRIAC121.706717
4. Мartyak R. The Craven reaction with 2-aryl-1,4-benzoquinones / R. Маrtyak, V. Маtiychuk, М. Оbushak // Visnyk Lviv Univ. Ser. Chem. – 2021. – Iss. 62. – P. 220–226. http://dx.doi.org/10.30970/vch.6201.220
5. Matiichuk Y. Synthesis and antimicrobial activity of 4-(5-aryl-2-furoyl)morpholines and 4-[(5-aryl-2-furyl)carbonothioyl] morpholines / Y. Matiichuk, Y. Gorak, R. Martyak, T. Chaban, V. Ogurtsov, I. Chaban, V. Matiychuk // Pharmacia. – 2021. – Vol. 68. No 1. – P. 175–179. https://doi.org/10.3897/pharmacia.68.e46942
6. Мartyak R.L. Synthesis and antimicrobial activity of derivatives of 4-R-benzylpyrrol-3-carboxylic acid esters / R.L. Маrtyak, А.М. Grozav, N.D. Yakovychuk, V.V. Кinzhybalo, V.S. Маtiychuk // Voprosy khimii i khimicheskoi tekhnologii – 2020. – No. 5. – P. 36–45. http://dx.doi.org/10.32434/0321-4095-2020-132-5-36-45
7. Маrtyak R. Аrylnaphthoquinones. 8. Synthesis of 6-arylbenzo[a]phenazines / R. Маrtyak, М. Rohovyk // Visnyk Lviv Univ. Ser. Chem. – 2020. – Iss. 61. Pt. 2. – P. 289–293. https://doi.org/10.30970/vch.6102.289
8. Маrtyak R. Аrylnaphthoquinones. 7. Synthesis of angular heterocycles from 2-aryl-1,4-naphthoquinones / R. Маrtyak, М. Rohovyk, Т. Nestoruk // Visnyk Lviv Univ. Ser. Chem. – 2019. – Iss. 60. Pt. 2. – P. 302–308. https://doi.org/10.30970/vch.6002.302
9. Маrtyak R. Synthesis and antitumor activity of 4-benzylpyrrole derivatives / R. Маrtyak, D. Frolov, V. Маtiychuk, М. Оbushak // Visnyk Lviv Univ. Ser. Chem. – 2018. – Iss. 59. Pt. 2. – P. 276–285. https://doi.org/10.30970/vch.5902.276
10. Shyyka O.Ya. Facile synthetic route to benzo[c]chromenones and thieno[2,3-c]chromenones / O.Ya. Shyyka, R.L. Martyak, M.A. Tupychak, N.T. Pokhodylo, M.D. Obushak // Synth. Commun. – 2017. – Vol. 47. No 24. – P. 2399–2405. https://doi.org/10.1080/00397911.2017.1380833
11. Маrtyak R. Synthesis and antitumor activity of 7-aryl-5-hydroxy-1,3-benzoxathiol-2-ones / R. Маrtyak, V. Маtiychuk, V. Skrobala // Visnyk Lviv Univ. Ser. Chem. – 2017. – Iss. 58. Pt 2. – P. 261–269. http://publications.lnu.edu.ua/bulletins/index.php/chemisrty/article/view/7442/7441
12. Маrtyak R. Аrylnaphthoquinones. 6. Synthesis of 3-aryl-1,2-naphthoquinones and their reactions with 1,3-dicarbonyl compounds / R. Маrtyak, І. Bahniuk, М. Оbushak // Visnyk Lviv Univ. Ser. Chem. – 2016. – Iss. 57. Pt. 2. – P. 273–279. http://publications.lnu.edu.ua/bulletins/index.php/chemisrty/article/view/6164/6174
13. Маrtyak R. Interaction of 1-aryl-1H-tetrazolo-5-thioles with 1,4-quinones / R. Маrtyak // Visnyk Lviv Univ. Ser. Chem. – 2015. – Iss. 56. Pt. 2. – P. 284–292. http://publications.lnu.edu.ua/bulletins/index.php/chemisrty/article/view/6391/6395
14. Маrtyak R. Аrylnaphthoquinones. 5. Synthesis of 4-aryl-5-hydroxy-7,8-dimethylnaphtho[2,1-d]-[1,3]оxathiol-2-оnes / R. Маrtyak // Visnyk Lviv Ser. Chem. – 2014. – Iss. 55. Pt. 2. – P. 316–321. http://publications.lnu.edu.ua/bulletins/index.php/chemisrty/article/view/6505/6506
15. Маndzyuk L. Cyclization of 2-(3-аryl-4,5-dihydro-1Н-5-pyrazolyl)-4-chlorophenols with аromatic aldehydes / L. Маndzyuk, Yu. Ostapiuk, R. Vasylyshyn, О. Bodnarchuk, R. Маrtyak, М. Оbushak // Visnyk Lviv Ser. Chem. – 2013. – Iss. 54. Pt. 2. – P. 236–242. http://publications.lnu.edu.ua/bulletins/index.php/chemisrty/article/view/6628/6626
16. Маrtyak R. Аrylnaphthoquinones. 4. Reactions of 2-аryl-6,7-dimethyl-1,4-naphthoquinones with diamines / R. Маrtyak, М. Оbushak // Visnyk Lviv Univ. Ser. Chem. – 2012. – Iss. 53. – P. 227–231. http://publications.lnu.edu.ua/bulletins/index.php/chemisrty/article/view/6803/6811
17. Маrtyak R. Аrylnaphthoquinones. Synthesis of 2-аryl-2,3-epoxy-2,3-dihydro-6,7-dimethyl-1,4-naphthoquinones and their reactions / R. Маrtyak, М. Оbushak, V. Маtiychuk // Proc. Shevchenko Sci. Soc. Ser. Chem. Biochem. – 2010. – Vol. 25. – P. 142–151.
18. Маrtyak R. The Nenitzescu-type condensation of 2-aryl-1,4-benzoquinones with enamines / R. Маrtyak, М. Оbushak, О. Таratula // Visnyk Lviv Univ. Ser. Chem. – 2009. – Iss. 50. – P. 194–202.
19. Маrtyak R. Аrylnaphthoquinones. 2. Diels-Alder reaction of 2-aryl-1,4- Synthesis of 2-bromo-6,7-dimethyl-3-phenyl-1,4-naphthoquinone and interaction with bases / R. Маrtyak, М. Оbushak, V. Маtiychuk // Visnyk Lviv Univ. Ser. Chem. – 2006. – Iss. 47. – P. 138–146.
20. Оbushak М. Synthesis of substituted benzo[b]thiophenes by the reaction of thionyl chloride with cinnamic acid derivatives and similar reagents / М. Оbushak,  R. Маrtyak, V. Маtiychuk // Proc. Shevchenko Sci. Soc. Ser. Chem. Biochem. – 2005. – Vol. XV. – P. 94–109.
21. Matiychuk V.S. 3-Aryl-2-chloropropanals in Hantzsch synthesis of pyrroles / V.S. Matiychuk, R.L. Martyak, M.D. Obushak, Yu.V. Ostapiuk, N.I. Pidlypnyi // Chem. Heterocycl. Compd. – 2004. – Vol. 40. No 9. – P. 1218–1219. https://doi.org/10.1023/B:COHC.0000048299.17625.7f
22. Obushak M.D. Synthesis of heterocycles from the products of anionic arylation of unsaturated compounds. 7. Products of haloarylation of acrylic acid and its esters in the synthesis of benzo[b]thiophene derivatives / M.D. Obushak, V.S. Matiichuk, R.L. Martyak // Chem. Heterocycl. Compd. – 2003. – Vol. 39. No 7. – P. 878–884. https://doi.org/10.1023/A:1026190103546
23. Obushak M. Synthesis of heterocycles on the basis of products of the reactions of arenediazonium salts with unsaturated compounds / М. Оbushak, V. Маtiychuk, V. Каrpyak,  R. Маrtyak // Proc. Shevchenko Sci. Soc. Ser. Chem. Biochem. – 2003. – Vol. 10. – P. 54–75.
24. Маrtyak R. Аrylnaphthoquinones. 1. Diels-Alder reaction of 2-aryl-1,4- Synthesis of 5-hydroxy-7,8-dimethyl-4-(4-methylphenyl)naphtho[2,1-d][1,3]oxathiol-2-one / R. Маrtyak, М. Оbushak, V. Маtiychuk // Visnyk Lviv Univ. Ser. Chem. – 2006. – Iss. 47. – P. 138–146.
25. Obushak M.D. Synthesis of heterocycles on the basis of arylation products of unsaturated compounds. Part 9. Dialkyl 2,6-diamino-4-arylfuro[2′,3′:4,5]benzo[b]furan-3,7-dicarboxylates from 2-aryl-1,4-benzoquinones and cyanoacetic esters / M.D. Obushak, R.L. Martyak, V.S. Matiychuk // Polish J. Chem. – 2002. – Vol. 76. No 10. – P. 1419–1424.
26. Маtiychuk V.S. Synthesis of phenikaberane analogues with aryl substitutions / V.S. Маtiychuk, R.L. Маrtyak, М.D. Оbushak, R.Ya. Vasylyshyn // Farmatsevtychnyi zhurnal. – 2002. – No. 6. – P. 45–51.
27. Obushak N.D. Synthesis of heterocycles based on products of anion arylation of unsaturated compounds. 5. Reaction of 2-aryl-1,4-benzoquinones with thiourea / N.D. Obushak, V.S. Matiichuk, R.L. Martyak // Chem. Heterocycl. Compd. – 2001. – Vol. 37. No 7. – P. 909–915. https://doi.org/10.1023/A:1012420128922
28. Obushak N.D. Synthesis of heterocycles on the basis of anion arylated products of unsaturated c Part 4. Cyclocondensation of 3-aryl-2-halo(thiocyanate)propionitriles / N.D. Obushak, V.S. Matiichuk, R.L. Martyak, N.I. Ganushchak // Chem. Heterocycl. Compd. – 1999. – Vol. 35. No 1. – P. 93–96. https://doi.org/10.1007/BF02251670
29. Obushak N.D. Synthesis of 4-amino-5-arylmethyl-2-bromothiazoles / N.D. Obushak, V.S. Matiichuk, N.I. Ganushchak, R.L. Martyak // Chem. Heterocycl. Compd. – 1997. – Vol. 33. No 8. – P. 1000. https://doi.org/10.1007/BF02253182

Patents

1. Пат. 128135 Україна МПК C07D 311/0 Спосіб одержання арил- та гетарил-анельованих 6-гідрокси-2Н-хромен-2-онів / Шийка О.Я., Мартяк Р.Л., Тупичак М.А., Походило Н.Т., Обушак М.Д.; заявник і власник Львівський національний університет імені Івана Франка. – № u 201801132; заявл. 06.02.2018; Опубл. 10.09.2018. Бюл. № 17.
2. Пат. 71674 Україна МПК C07D 207/08. Спосіб одержання заміщених 4-бензилпіролів / Мартяк Р.Л., Обушак М.Д., Матійчук В.С., Підлипний Н.І.; заявник і власник Львівський національний університет імені Івана Франка. – № u 201115041; заявл. 19.12.2011; Опубл. 25.07.2012. Бюл. № 14.
3. Пат. 71671 Україна МПК C07D 209/04. Спосіб одержання етил 6-арил-5-гідрокси-1-R-2-метиліндол-3-карбоксилатів / Мартяк Р.Л., Обушак М.Д., Матійчук В.С.; заявник і власник Львівський національний університет імені Івана Франка. – № u 201115028; заявл. 19.12.2011; Опубл. 25.07.2012. Бюл. № 14.

Was born in Zashkiv, Zhovkva district, Lviv region.

1997 – graduated from the Faculty of Chemistry of Ivan Franko Lviv State University.

1997–1998 – laboratory assistant of the Department of Organic Chemistry.

1998–2001 – studied at the postgraduate course of the Department of Organic Chemistry of Ivan Franko National University of Lviv.

Since 2001 has been a junior researcher, since 2004 an assistant professor, and since 2010 an associate professor of the Department of Organic Chemistry of the Ivan Franko National University of Lviv.

2004 – defended dissertation for the degree of Candidate of Chemical Sciences in Organic Chemistry (topic “Synthesis of condensed heterocyclic compounds based on Meerwein reaction products”).

2011–2020 – lecturer at the College of Natural Sciences of the Ivan Franko National University of Lviv (part-time employee).

In 2011 was awarded the academic title of Associate Professor of Organic Chemistry.

2021-till now – associate dean of the Faculty of Chemistry for scientific, teaching and educational work.

Member of the Scientific and Technical Council of Ivan Franko National University of Lviv.

Member of the Academic Council of the Faculty of Chemistry of Ivan Franko National University of Lviv.

Member of the Shevchenko Scientific Society since 2013.

State budget research works:

• Project ХО-05Ф “Development of resource-efficient methods for the synthesis of heterocyclic compounds for optoelectronics and screening for bioactivity” (0124U001445), 2024–2026 (executor of the project, 2024).
• Project ХО-34Ф “Functionally oriented design of new azoles – biologically active substances and analytical reagents” (0122U001615), 2022–2024 (executor of the project, 2022-2023).
• Project П2–БФ “New substances, materials, types of matter and approaches to energy saving and environmental protection” (0121U113567), 2021–2025 (executor of the project, 2021).
• Project ХО-74Ф “One-reactor and tandem reactions in the design of heterocycles and search of bioactive compounds and materials for organic electronics” (0118U003610), 2018–2020 (executor of the project, 2018).

International projects and grants:

• Research project M/74-2021; 19.11.2021 in the framework of Ukrainian–Lithuanian scientific and technical cooperation “Donor-substituted 1,2,3-triazole derivatives as materials for organic light-emitting diodes” (0120U103594), 2020–2021 (executor of the project, 2021).

• Recognition of the Ivan Franko National University of Lviv (2024);
• Recognition of the Department of Education and Science of Lviv Regional State Administration (2024).

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