International Partnership

Project НХ-010316
Project Title: “Search for New Structural Types”.
Validity: 01.03.2016-31.10.2019
Scientific supervisor: Corr. National Academy of Sciences of Ukraine, prof. Gladyshevsky R.E.
Source of funding: “Materials of the Phase Data System” company (Vitsnau, Switzerland).
Amount of financing: 348934 UAH in 2018
Participants from the University: Associate Professor Muts N.M., Assoc. Pukas S.Ya., st.n.sp. Demchenko P.Yu.,
st.n.p. Maniak MB, st.n.p. Milianchuk H.Yu., senior researcher Tokaichuk Ya.O., mn.sp. Zaremba OI
Brief information: the crystalline structure of separate multicomponent intermetallic compounds of the f-, d- and p-elements, both new and those whose existence was reported in the literature, was determined, but their structures were not completely deciphered.

Grant-in-Aid International Center for Diffraction Data Grant
Title of the project: “X-ray powder diffractograms of new intermetallic compounds”.
Validity: 01.04.2017-31.03.2018
Scientific supervisor: Corr. National Academy of Sciences of Ukraine, prof. Gladyshevsky R.E.
Source of funding: International Center for Diffraction Data ICDD (USA).
Funding: $ 8750.
Participants from the University: Associate Professor Pukas S.Ya., st.n.sp. Demchenko P.Yu., st.n.sp. Tokaychuk Ya.O., n.p. Semuso N.Z.
Brief information: The crystal structure of the compounds {Ba, Sc} -Pd-Al, La-Tb-Ga, Ce-Dy-Ga, {Pr, Dy} -Al-Ga, {Zr, Hf} -Al -Ge, Gd-Ge-Sn, Ce-Cr-Ag-Al, Pr-Ta-Ag-Al, Ce-Gd-Ga-Si, La-Ga-Ge-Si, {Sm, Tm} -Mn-Al -Ge, Yb-Fe-Al-Ge, {Gd, Tm} -Ni-Al-Ge, {Ho, Lu} -Fe-Ni-Al-Ge, Y-Er-Fe-Al-Ge, {Gd, Er} -Ni-Co-Al-Ge,
Y- {Sm, Er, Dy} -Ni-Al-Ge. The diffractograms of the compounds are created in digital format and included in the scientific base of the International Center for Diffraction Data.

Nanoparticles for drug delivery project
Validity: 18.10.2017-10.01.2018
Source of funding: Institute for Biomedical Research Novartis (USA).
Amount of funding: 86700 UAH.
Participants from the department: associate professor Ostapyuk Yu.V., art. sciences co-worker It was like N.T., Art. sciences co-worker Shiika O.Ya.
Brief information: An analysis of the use of nanotechnologies for the delivery of drugs. The types of nanoparticles that can be used for efficient delivery are analyzed. The possibilities of modification of drugs or carriers were studied, regularities of the influence of size, structure, charge, structure of nanoparticle on the efficiency of delivery to the target were established.

Antibody Masking Project
Validity: 18.10.2017-02.12.2017
Source of funding: Institute for Biomedical Research Novartis (USA).
Amount of funding: 47250 UAH
Participants from the department: associate professor Ostapyuk Yu.V., art. sciences co-worker It was like N.T., Art. sciences co-worker Shiika O.Ya.
Brief information: An analysis of antibody masking techniques was performed. Methods of protecting antibodies of different types have been analyzed in order to increase the life time of substrates. The analysis of use of linkers of various nature in the technology of masking antibodies is carried out. The achievements of top companies / organizations for solving these problems were investigated.

Albumin binders project
Validity: 12.01.2018-10.05.2018
Source of funding: Institute for Biomedical Research Novartis (USA).
Funding amount: 90500 UAH.
Participants from the department: associate professor Ostapyuk Yu.V., art. sciences co-worker It was like N.T., Art. sciences co-worker Shiika O.Ya.
Brief information: The variability of binders and molecules capable of covalent and non-covalently bonded to albumin has been studied. The analysis of the level of affinity of Binders of various nature is analyzed. Dependence of the value of albumin affinity on the lifetime of conjugates noncovalently bound via binders with albumin is shown.

Protein Conjugate Project
Validity: Jan 12, 2011 – until now
Source of funding: Institute for Biomedical Research Novartis (USA).
Funding amount: 45500 UAH.
Participants from the department: associate professor Ostapyuk Yu.V., art. sciences co-worker It was like N.T., Art. sciences co-worker Shiika O.Ya.
Brief information: An analysis of methods and approaches for the modification of natural peptides. The search for methods of selective modification of peptides by means of chemical, enzymatic reactions and interactions of non-covalent nature has been carried out. The possibility of modification of amino acid fragments in peptides has been studied, universality, accessibility, selectivity is shown.

Project “Nanoparticles 2.0”
Validity: 07/03/2018 to now
Source of funding: Institute for Biomedical Research Novartis (USA).
Amount of financing: 22000 UAH.
Participant from the department: associate professor Ostapyuk Yu.V.
Brief information: The analysis of nanoparticle modification methods is carried out. Examples of selective targeting of drugs using nanoparticles are found. The influence of size, charge, type on the delivery efficiency, the universality, accessibility, selectivity is shown.

Active Drug Targeting for Musculoskeletal Disorders Project
Validity: 12.03.2018 – to this day
Source of funding: Institute for Biomedical Research Novartis (USA).
Amount of funding: UAH 260000
Participants from the department: art. sciences co-worker It was like N.T., Art. sciences co-worker Shiika O.Ya.
Brief information: An analysis of the selective targets of the skeletal muscle system has been performed. We have found examples of selective administration of drugs for muscle, cartilage, nervous, bone tissue in the treatment of various diseases, in particular, dystrophy, neuropathy, osteoporosis. A variety of target molecules is shown and the effectiveness of their binding to the targets is investigated. The binding, biodistribution, conjugate lifetime, and the like are studied.

Project “Biological Databases”
Validity: January 15, 2018-11.03.2018
Source of funding: Institute for Biomedical Research Novartis (USA).
Amount of funding: 86300 UAH.
Participants from the department: art. sciences co-worker It was like N.T., Art. sciences co-worker Shiika O.Ya.
Brief information: The analysis of available databases for biological units is carried out. The advantages and disadvantages of software and universal platforms are analyzed. The analysis of the basic parameters and characteristics of electronic laboratory journals for working with biological substances is carried out.

Cooperation with foreign scientific institutions and firms (academic internships, grants, contracts, number of joint publications, joint scientific events, invitations of foreign scientists).
1. Australian Organization for Nuclear Research and Technology, Sydney, Australia
(according to the results of cooperation published 1 article);
2. Vienna University, Austria (by the results of the collaboration published 1 monograph, 3 articles);
3. Vienna Technical University, Austria (as a result of cooperation published 1 monograph, 1 article and theses 4 reports at conferences);
4. Technical University of Denmark, M. Lingby (1 article published on the results of the collaboration);
5. Ain Shams University, Cairo, Egypt (1 article published on the results of the collaboration);
6. Bologna University, Bologna, Italy (according to the results of the collaboration published 1 article);
7. Southwestern University, Chongqing, China (as a result of collaboration published 1 article);
8. Latvian University, Riga, Latvia (as a result of cooperation published Thesis 1 report at the conference);
9. Kaunas University of Technology, Lithuania (as a result of cooperation published
4 articles and theses 2 reports at conferences);
10. University of Putra, Malaysia (2 articles published on the results of the collaboration);
11. Helmholtz Center Dresden-Rossendorf, Dresden, Germany (1 article was published on the results of the collaboration);
12. Institute of Technology, Karlsruhe, Germany (as a result of the collaboration published 1 article and theses 1 report at the conference);
13. Max Planck Institute for Solid State Research, Stuttgart, Germany (based on the results of the collaboration published 1 monograph, 1 article);
14. Max Planck Institute for Solid State Chemical Physics, Dresden, Germany (6 articles and theses 4 reports at conferences were published as a result of the collaboration; scientific study of Prospekt Leningrad, Axelrud LG, 01.03.2018- 31.05.2018 Ph.D., scientific internship M.Sc. Matcelko O.V., 15.10.2017-14.02.2018, 07.11.2018-12.08.2018);
15. Munich Technical University, Germany (as a result of the collaboration published 1 article and abstracts of 3 reports at conferences);
16. Technical University “Freiberg Mining Academy”, Freiberg, Germany (according to the results of cooperation published 1 article, scientific internship of N.S. Levitsky VO, 09/23/2012, 30.09.2019);
17. Chemnitz University of Technology, Germany (the results of the collaboration published 1 article and theses 1 report at the conference);
18. Münster University, Germany (the results of the collaboration published 2 articles and theses 2 reports at conferences;);
19. German Electronic Synchrotron (DESY), Hamburg (according to the results of the collaboration published 1 article);
20. Institute of Manufacturing Technologies and Advanced Materials of Fraunhofer, Bremen, Germany (the results of the collaboration published the abstracts of 1 report at the conference);
21. Institute of Low Temperatures and Structural Studies named after. V. Tzhebyatovsky PAN Wroclaw, Poland (6 articles and theses 7 reports at conferences were published on the results of cooperation);
22. AGH University of Science and Technology, Krakow, Poland (the results of cooperation published theses 1 report at the conference);
23. University of Warsaw, Poland (by the results of the collaboration published 1 article);
24. Wroclaw University, Poland (by the results of cooperation published 3 articles and theses 4 reports at conferences, scientific internship of academic degree, associate professor Gorak Yu.I. 20-27.05.2018 and associate professor. Pavlyuk O., June 24, 2007, July 2, 2018);
25. Gdańsk Technical University, Poland (as a result of cooperation published 1 article);
26. Rzeszow University, Poland (2 articles and theses were published on the results of the collaboration 1 report at the conference);
27. Opole Technical University, Poland (as a result of cooperation published 4 articles and theses 2 reports at conferences);
28. Czestochowa Technical University, Poland (as a result of cooperation published 6 articles and theses 2 reports at conferences);
29. Yana Dlugosha University, Czestochowa, Poland (15 articles and theses published 8 reports at conferences were published on the results of cooperation);
30. Jagiellonian University, Krakow, Poland (as a result of cooperation published 4 articles and theses 5 reports at conferences);
31. Ivan Pavel II Catholic University, Lublin, Poland (the results of the collaboration published the abstracts of 2 reports at conferences);
32. University of Casimir the Great, Bydgoszcz, Poland (2 articles have been published on the results of the collaboration);
33. King Saud University, Riyadh, Saudi Arabia (2 articles published on the results of the collaboration);
34. Institute of Experimental Physics, Slovak Academy of Sciences, Kosice, Slovakia (according to the results of cooperation published 1 article);
35. Institute of Materials and Mechanical Engineering of the Slovak Academy of Sciences, Bratislava, Slovakia (according to the results of the collaboration published 1 article);
36. University of Veterinary Medicine and Pharmacy, Kosice, Slovakia (according to the results of cooperation published 1 article);
37. Slovak University of Technology, Bratislava, Slovakia (according to the results of the collaboration 1 article and 1 thesis of the report have been published);
38. Paul Josef Safarika University, Kosice, Slovakia (1 article published on the results of the collaboration);
39. Josef Stefan Institute, Ljubljana, Slovenia (as a result of cooperation published 5 articles and theses 2 reports at conferences);
40. State University of North Carolina, Raleigh, USA (according to the results of the collaboration, 1 article was published);
41. University of Nebraska, Omaha, USA (the results of the collaboration published theses 1 report at the conference);
42. International Center for Diffraction Data, ICDD, Newton Skvear, USA (Grant “X-ray powder diffractograms of new intermetallic compounds”);
43. The Institute for Biomedical Research, Novartis, Cambridge, USA (7 scientific projects are implemented: “Nanoparticles for drug delivery”, “Anti-mummification”, “Albumin binding”, “Protein conjugates”, “Nanoparticles 2.0″, ” Active referral for diseases of the skeletal system “,” Database of biological units “)
44. University of Jyväskylä, Finland (1 article published on the results of the collaboration);
45. Academy Abo University, Turku, Finland (the results of the collaboration have published 1 section of the monograph and 6 articles);
46. ​​European Center for Synchrotron Research, Grenoble, France (according to the results of the collaboration published 1 article and theses 1 report at the conference);
47. Neel Institute of the National Center for Scientific Research, Grenoble, France (according to the results of cooperation published 1 article and theses 1 report at the conference; scientific internship of the M.Sc. Levitsky V.O., 01.11.2017-30.11.2017);
48. Institute of Chemistry and Materials of the National Center for Scientific Research, Tue, France (2 articles published on the results of the collaboration);
49. University of Angers, Angers, France (1 article published on the results of the collaboration);
50. University of Rennes 1, Rennes, France (as a result of collaboration published 1 monograph);
51. Institute of Physics of the Czech Academy of Sciences, Prague, Czech Republic (the results of the collaboration published the theses of 1 report at the conference);
52. Charles University, Prague, Czech Republic (as a result of cooperation published 1 article and abstracts of 5 reports at conferences; scientific internship st.n.sp. Milianchuk H.U., 21.08.2017-31.12.2017);
53. Y. Geirovsky Institute of Physical Chemistry, Prague, Czech Republic (by the results of cooperation published theses 1 reports at the conference);
54. University of Geneva, Switzerland (1 article published on the results of the collaboration);
55. Materials Phases Data System, Switzerland (2 scientific projects: “Fundamental Research in the Field of Natural Sciences” and “Finding New Structural Types”);
56. Lund University, Sweden (by the results of cooperation published 1 article and abstracts 1 report at the conference; scientific internship mn.sp. Oshchapovsky IV, Visby scholarship, 1.09.2017-31.08.2018);
57. Swedish University of Agricultural Sciences, Uppsala, Sweden (by the results of the collaboration published 1 article);
58. University of Uppsala, Sweden (the results of the collaboration have published 1 article, scientific internship of Sts., Saldan I.V, 01.10.2018-22.02.2019).