Mykola Obushak

Position: Chairperson, Department of Organic Chemistry

Scientific degree: Doctor of Chemical Sciences

Academic status: Professor

Phone (office): (032) 260-03-96

Email: m_obushak@lnu.edu.ua

Google Scholar profile: scholar.google.com.ua

Research interests

https://www.researchgate.net/profile/Mykola_Obushak

Cyclization reactions, synthesis of heterocyclic compounds, homogeneous-catalytic reactions of diazonium salts, methal-complex catalysis, domino reactions.

Key words: heterocycles, heterocyclizations, arylation, Meerwein reaction, arenediazonium salts, thiazole derivatives, 4-thiazolidinone derivatives, isocoumarins, furan derivatives, palladium-catalyzed reactions.

Selected publications

1. Lytvyn R.Z., Neshchadin A.О., Pitkovych Kh.Y., Horak Yu.I., Grazulevicius J.V., Lis T., Kinzhybalo V., Obushak M.D. A simple and convenient synthesis of 3-arylpyran-2-ones via Meerwein reaction // Tetrahedron Lett. – 2016 – Vol. 57, № 1. – Р. 118–121. http://www.sciencedirect.com/science/article/pii/S0040403915303841

2. Zubkov F.I., Zaytsev V.P, Mertsalov D.F., Nikitina E.V., Dorovatovskii P.V., Khrustalev V.N., Horak Yu.I., Lytvyn R.Z., Homza Yu.V., Obushak M.D., Varlamov A.V. Easy construction of furo[2,3-f]isoindole core by the IMDAV reaction between 3-(furyl)allylamines and α,β-unsaturated acid anhydrides // Tetrahedron – 2016 – Vol. 72, № 18. – Р. 2239–2253. http://www.sciencedirect.com/science/article/pii/S0040402016301569

3. Yelenich O.V., Lytvyn R.Z., Skrypska O. V., Pitkovych Kh.Ye., Kachkovskii A.D., Obushak M.D., Yagodinets P.I. Synthesis, Nature of Electronic Transitions, and Absorption Spectra of the Dye Based on 4-(Methyl-1-{2-[4-(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)phenyl]-2-oxoethyl}pyridinium Bromide // Russ. J. Gen. Chem. – 2016. – Vol. 86, No. 8. – P. 1838–1844. http://link.springer.com/article/10.1134/S1070363216080107

4.Elenich O.V., Lytvyn R.Z., Skripskaya O.V., Lyavinets O.S., Pitkovych Kh.E., Yagodinets P.I., Obushak M.D. Synthesis of Nitrogen-Containing Heterocycles on the Basis of 3-(4-Acetylphenyl)-1-methylquinolin-2(1H)-one // Russ. J. Org. Chem. – 2016. – Vol. 52, No. 3. – P. 373–378. http://link.springer.com/article/10.1134/S1070428016030131

5. Dibrivnyi V.M., Sobechko I.B., Puniak M.R., Horak Yu.I., Obushak M.D., Van-Chyn-Syan Yu.Ya., Marshalek A.S., Velychkivska N.I. Thermodynamic properties of 5(nitrophenyl)furan-2-carbaldehyde isomers // Chemistry Central Journal. – 2015 – Vol. 9:67. – Р. 1–7. https://ccj.springeropen.com/articles/10.1186/s13065-015-0144-x

6. Ostapiuk Yu.V., Matiychuk V.S., Obushak M.D. Synthesis and anticancer properties of 2-(4-amino-5-methyl-4H-[1,2,4]triazol-3-ylsulfanyl)-N-(5-R-benzylthiazol-2-yl)-acetamides // J. Org. Pharm. Chem. – 2015. – Т. 13, вип. 4. – С. 27–31. http://nuph.edu.ua/wp-content/uploads/2016/01/ZhOFH4-15-27-31.pdf

7. Pokhodylo N.T., Shyyka O.Ya., Matiychuk V.S., Obushak M.D. New Convenient Strategy for Annulation of Pyrimidines to Thiophenes or Furans via the One-pot Multistep Cascade Reaction of 1H-Tetrazoles with Aliphatic Amines // ACS Comb. Sci. – 2015. – Vol. 17, № 7. – P. 399–403. http://pubs.acs.org/doi/abs/10.1021/co5001376

8. Horak Yu.I., Lytvyn R.Z., Homza Yu.V., Zaytsev V.P., Mertsalov D.F., Babkina M.N., Nikitina E.V., Lis T., Kinzhybalo V., Matiychuk V.S., Zubkov F.I., Varlamov A.V., Obushak M.D. The Intramolecular Diels-Alder Vinylfuran (IMDAV) Reaction: a Short Approach to Aza-analogues of Pinguisane-Type // Tetrahedron Lett. – 2015. – Vol. 56, № 30. – P. 4499–4501. http://www.sciencedirect.com/science/article/pii/S0040403915009570

9. Sobechko I.B., Van-Chin-Syan Yu.Ya., Gorak Yu.I., Kochubei V.V., Prokop R.T., Velichkivska N.I., Dibrivnyi V.N., Obushak M.D. Thermodynamic Characteristics of the Melting and Dissolution of Crystalline Furan-2-carboxylic and 3-(Furyl)-2-propenoic in Organic Solvent // Russ. J. Phys. Chem. A – 2015. – Vol. 89, № 6. – Р. 919–925. http://link.springer.com/article/10.1134/S003602441506028X

10. Sucman N., Pogrebnoi V., Obushak M., Melnic E., Kravtsov V., Macaev F. The synthesis of new spirolactones from substituted isatins // Chem. J. Mold. – 2015. – Vol. 10, № 1. – P. 64–70. http://www.cjm.asm.md/taxonomy/term/35

11. Pokhodylo N.T., Shyyka O.Ya., Obushak N.D. Ethyl 2-Aminothiophene-3-Carboxylates in the Synthesis of Isomeric Thienopyridines // Сhem. Heterocycl. Compds – 2015. – Vol. 50, № 12. – Р.1748–1755. http://link.springer.com/article/10.1007/s10593-015-1647-z

12. Turytsya V.V., Ostapiuk Yu.V., Matiychuk V.S., Obushak M.D. Synthesis of 3-aryl/methoxycarbonyl-3,4-dihydroisocoumarin-6-carboxylic acid derivatives // J. Heterocycl. Chem. – 2014. – 2014 – Vol. 51, №. 6. – P. 1898–1901. http://onlinelibrary.wiley.com/doi/10.1002/jhet.1975/full

13. Yelenich О.V., Skrypska O.V., Lytvyn R.Z., Neshchadin A.O., Obushak M.D., Kachkovskii A.D., Yagodinets P.I. New biscyanine dye based on 1-{2-oxo-2-[4-(2-oxo-2H-chromen-3-yl)phenyl]ethyl}-4-methylpyridinium bromide. Electron transitions and electronic spectra // Russ. J. Gen. Chem. – 2014. – Vol. 84, № 11. – P. 2114–2119. ttp://link.springer.com/article/10.1134/S1070363214110127

14. Pokhodylo N.T., Shyyka O.Ya., Obushak M.D. Facile and efficient one-pot procedure for thieno[2,3-e][1,2,3] triazolo[1,5-a]pyrimidines preparation // Synth. Commun. – 2014.– Vol. 44, № 7.– P. 1002–1006. http://www.tandfonline.com/doi/full/10.1080/00397911.2013.840729

15. Pokhodylo N.T., Savka R.D., Obushak M.D. Synthesis of 3,4-dihydro-2H-thiopyrans and [3,4-c]chromenones containing 1,2,3-triazole moiety by the domino reaction thionation–hetero-Diels–Alder // Chem. Нeterocycl. Сompds. – 2014. – Vol. 50, №. 4. – P. 544–549. http://link.springer.com/article/10.1007/s10593-014-1505-4

16. Skripskaya O.V., Feilo N.O., Neshchadin A.O., Elenich O.V., Lytvyn R.Z., Obushak N.D., Yagodinets P.I. Synthesis of Nitrogen Heterocycles Underlain by Application of 3-(4-Acetylphenyl)-2H-coumarin // Russ. J. Org. Chem. – 2013. – Vol. 49. No. 11. – Р. 1655−1660. http://link.springer.com/article/10.1134/S1070428013110158

17. Pokhodylo N.T., Matiichuk V.S., Obushak M.D. Synthesis of 1-(1-Aryl-1H-1,2,3-triazol-4-yl)-β-carboline Derivatives // Russ. J. Org. Chem. – 2014. – Vol. 50, № 2. – Р. 275−279. http://link.springer.com/article/10.1134/S1070428014020225

18. Savka R.D., Pohodylo N.T., Obushak M.D. Effective Method of β-Keto Sulfones Synthesis // Russ. J. Org. Chem. – 2014. Vol. 50, №. 2. P. 296–297. http://link.springer.com/article/10.1134/S1070428014020274

19. Pokhodylo N.T., Shiika O.Ya., Obushak M.D. Synthesis of thieno[2,3-e][1,4]diazepine derivatives // Russ. J. Org. Chem. – 2014. Vol. 50, №. 3. P. 449–451. http://link.springer.com/article/10.1134/S1070428014030282

20. Kozlov N.G., Zhikharko Yu.D., Lytvyn R.Z., Gorak Yu.I., Skakovskii E.D., Baranovskii A.V., Basalaeva L.I., Obushak M.D. Synthesis of 12-Hetaryl-9,9-dimethyl-7,8,9,10-tetrahydrobenzo[a]acridin-11(12H)-ones // Russ. J. Org. Chem. – 2014. – Vol. 50, № 6. – Р. 833–839. http://link.springer.com/article/10.1134/S107042801406013X

21. Sobechko I.B., Van-Chin-Syan Yu.Ya., Kochubei V.V., Prokop R.T., Velichkivskaya N.I., Gorak Yu.I., Dibrivnyi V.N., Obushak M.D. Thermodynamic properties of furan-2-carboxylic and 3-(2-furyl)-2-propenoic acids // Russ. J. Phys. Chem. A – 2014. – Vol. 88, № 12. – Р. 2046–2053. http://link.springer.com/article/10.1134/S0036024414120322

22. Kozlov N.G., Bondarev S.L., Zhikharko Yu.D., Knyukshto V.N., Lytvyn R.Z., Horak Yu.I., Obushak M.D., Basalaeva L.I. Synthesis, absorption spectra, and luminescence properties of dihydrobenzoacridinone derivatives // Russ. J. Appl. Chem. – 2014. – Vol. 87, № 6. – Р. 780–786. http://link.springer.com/article/10.1134/S1070427214060196

23. Bryhas А.O., Matiychuk V.S., Lis T., Kinzhybalo V., Smalius V.V., Obushak M.D. A four-step domino Knoevenagel–hetero-Diels–Alder reaction // Tetrahedron Lett. – 2013. – Vol. 54, № 42. – P. 5667–5670. http://www.sciencedirect.com/science/article/pii/S0040403913013531

24. Matiychuk V.S., Potopnyk M.A., Obushak M.D. A Simple and Efficient Synthesis of Ethyl 1-aryl-4-formyl-1H-pyrazole-3-carboxylates // J. Het. Chem. – 2013. – Vol. 50, № S1. – P. E43–E47. http://onlinelibrary.wiley.com/doi/10.1002/jhet.1042/full

25. Zubkov F.I., Zaytsev V.P., Obushak M.D., Ershova Yu.D., Mertsalov D.F., Sorokina E.A., Nikitina E.V., Gorak Yu.I., Lytvyn R.Z., Varlamov A.V. Synthesis of epoxyisoindolo[1,2-a]isoquinolinium salts by an intramolecular [2+4] cycloaddition reaction in 2-allyl-1-furylisoquinolinium halides // Chem. Heterocycl. Compd. – 2013. – Vol. 49, № 5. – С. 746–759. http://link.springer.com/article/10.1007/s10593-013-1306-1

26. Horak Yu.I., Lytvyn R.Z., Zubkov F.I., Nikitina E.V., Homza* Yu.V., Lis T., Kinzhybalo V., Obushak M.D. (4R*,4aR*,7aS*)-5-Oxo-6-phenyl-4a,5,6,7,7a,8-hexahydro-4H-furo[2,3-f]isoindole-4-carboxylic acid // Acta Cryst. Sect. E. – 2013. – E69, Pt. 2. – P. o273–o274. http://journals.iucr.org/e/issues/2013/02/00/cv5382/index.html

27. Teslenko Yu., Matiychuk V.S., Kinzhybalo V., Lis T., Obushak M.D. 5-Iodo-3-phenyl-2,1-benzoxazole //Acta Cryst. Sect. E – 2013. – E69, Pt. 4. – P. o508. http://scripts.iucr.org/cgi-bin/paper?S1600536813005862

28. Ostapiuk Yu.V., Obushak M.D., Matiychuk V.S., Naskrent M., Gzella A.K. A convenient method for the synthesis of 2-[(5-benzyl-1,3-thiazol-2-yl)imino]1,3-thiazolidin-4-one derivatives // Tetrahedron Lett. – 2012 – Vol. 53, № 5. – P. 543–545. http://www.sciencedirect.com/science/article/pii/S0040403911020466

29. Ostapiuk Yu.V., Matiichuk V.S., Pidlypnyi N.I., Obushak N.D. Convenient synthesis of 2-bromo ketones by the Meerwein reaction // Russ. J. Org. Chem. – 2012. – Vol. 48, № 4. – P. 519-522. http://link.springer.com/article/10.1134/S1070428012040094

30. Pokhodylo N.Т., Matiychuk V.S., Obushak M.D. Synthesis and Reaction of 2-Mercapto-3-arylpropionic Acids / Nazariy T. Pokhodylo, // Phosphorus, Sulfur, Silicon Relat. Elem. – 2012.– Vol. 187, № 7. – P. 850–858. http://www.tandfonline.com/doi/full/10.1080/10426507.2011.649503

31. Bryhas A.O., Horak Yu.I., Ostapiuk Yu.V., Obushak M.D., Matiychuk V.S. A new three-step domino Knoevenagel–hetero-Diels-Alder oxidation reaction // Tetrahedron Lett. – 2011. – Vol. 52, № 18. – P. 2324–2326. http://www.sciencedirect.com/science/article/pii/S0040403911003133

32. Matiychuk V.S., Potopnyk M.A., Luboradzki R., Obushak M.D. A new method for the synthesis of 1-aryl-1,2,4-triazole derivatives // Synthesis. – 2011. – № 11. – Р. 1799–1803. https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0030-1260026

33. Rad N.I., Teslenko Yu.O., Obushak M.D., Matiychuk V.S. Lytvyn R.Z. Oximes as Products in the Reactions of 5-Substituted 2-Nitrothiophenes with Arylacetonitriles // J. Heterocycl. Chem. – 2011. – Vol. 48, № 6. – P. 1371–1374. http://onlinelibrary.wiley.com/doi/10.1002/jhet.723/full

34. Lytvyn R., Horak Yu., Matiychuk V., Obushak M., Kinzhybalo V. 1-{5-[2-Chloro-5-(trifluoromethyl)phenyl]-2-thienyl}ethanone // Acta Cryst. Sect. E. – 2011. – E67. – o585. http://journals.iucr.org/e/issues/2011/03/00/ds2088/index.html

35. Obushak M.D., Horak Yu.I., Zaytsev V.P., Motorygina E.L., Zubkov F.I., Khrustalev VN. (6aR*,6bS*,11S*,11aS*)-6-(2-Furylmethyl)-5,12-dioxo-5,6,6a,6b,7,11,11a,12-octahydrofuro[3′,2′:5,6]isoindolo[2,1-a]quinazoline-11-carboxylic acid // Acta Cryst. Sect. E. – 2011. – E67, Pt. 11. – o3031–о3032. http://scripts.iucr.org/cgi-bin/paper?S160053681104311X

36. Pokhodylo N.T., Obushak N.D. Synthesis of 6-(5-sulfanyl-1H-tetrazol-1-yl)-2H-chromen-2-one and 5-methyl-1-(2-oxo-2H-chromen-6-yl)-1H-1,2,3-triazole-4-carboxylic acid // Russ. J. Org. Chem. – 2010. – Vol. 46, № 11. – Р. 1748–1749. http://link.springer.com/article/10.1134/S1070428010110242

37. Matiichuk V.S., Potopnyk M.A.,Obushak N. D. Synthesis of 2-aryl-4-(R-sulfanylmethyl)-3-methyl-6,7-dihydro-2H-pyrazolo[3,4-d]pyridazin-7-ones // Russ. J. Org. Chem. – 2010. – Vol. 46, № 10. – Р. 1550–1557. http://link.springer.com/article/10.1134/S1070428010100192

38. Pokhodylo N.T., Obushak N.D., Matiychuk V.S. Synthesis of 13-phenyl-9,15-dithia-2-azatricyclo-[9.3.1.03,8]pentadeca-1(14),3,5,7-tetraene // Chem. Heterocycl. Compd. – 2011. – Vol. 47, № 8. – Р. 1053–1054. http://link.springer.com/article/10.1007/s10593-011-0875-0

39. Zubkov F.I., Ershova J.D., Zaytsev V.P., Obushak M.D., Matiychuk V.S., Sokolova E.A., Khrustalev V.N., Varlamov A.V. The first example of an intramolecular Diels–Alder furan (IMDAF) reaction of iminium salts and its application in a short and simple synthesis of the isoindolo[1,2-a]isoquinoline core of the jamtine and hirsutine alkaloids // Tetrahedron Lett. – 2010. – Vol. 51, № 52. – P. 6822–6824. http://www.sciencedirect.com/science/article/pii/S0040403910018228

40. Pokhodylo N.T., Savka R.D., Pidlypnyi N.I., Matiychuk V.S., Obushak M.D. Synthesis of 2-Azido-1,3-thiazoles as 1,2,3-Triazole Precursors // Synth. Commun. – 2010. – Vol. 40, № 3. – P. 391–399. http://www.tandfonline.com/doi/full/10.1080/00397910902981274

41. Pokhodylo N.T., Matiychuk V.S., Obushak M.D. Synthesis of 1-(R-Phenyl)-5-(R-Methyl)-1 H -1,2,3-triazole-4-carboxylic Acids by One-Pot Tandem Reaction // Synth. Commun. – 2010. –Vol. 40, № 13. – Р. 1932–1038. http://www.tandfonline.com/doi/full/10.1080/00397910903174408

42. Pokhodylo N.T., Savka R.D., Shyyka O.Ya., Obushak M.D. Novel Selected Tandem Transformations of the Amino and Carbonyl/Nitrile Groups in the Gewald Thiophenes // Phosphorus, Sulfur, Silicon Relat. Elem. – 2010 – Vol. 185, № 10. – Р. 2092–2100. http://www.tandfonline.com/doi/full/10.1080/10426500903496739

43. Pokhodylo N.T., Matiychuk V.S., Obushak M.D. Synthesis of 3-aryl-3,6-dihydro-7H-[1,2,3]triazolo[4,5-d]pyrimidine-7-thiones as building blocks for potentially biologically active compounds // Phosphorus, Sulfur, Silicon Relat. Elem. – 2010. – Vol. 185, № 3. – P. 578–581. http://www.tandfonline.com/doi/full/10.1080/10426500902849573

44. Rad N., Teslenko Yu. Obushak M., Pavlyuk V., Marciniak B. 2-[(2Z,3E )-2-Hydroxyimino-5-phenyl-2,3-dihydro-3-thienylidene]-2-phenylacetonitrile // Acta Cryst. Sect. E. – 2010. – E66, Pt. 8. – o1924. http://scripts.iucr.org/cgi-bin/paper?S1600536810024955

45. Toze F.A.A., Ershova J.D., Obushak M.D., Zubkov F.I., Khrustalev V.N. 8a-Methyl-5,6,8,8a,9,10-hexahydro-10,12a-epoxy-isoindolo[1,2-a]isoquinolinium iodide // Acta Cryst. Sect. E. – 2010. – E66, Pt. 6. – o1388–o1389. http://scripts.iucr.org/cgi-bin/paper?S1600536810017903

46. Matiychuk V.S., Obushak N.D., Pidlypnyi N.I., Ostapiuk Yu.V., Voloshchuk R.М. Synthesis of heterocycles on the basis of products of arylation of unsaturated compounds. 22. 3-aryl-2-chloropropanals in the synthesis of N-aryl-5-(r-benzyl)-1,3-thiazolе-2-amines // Chem. Heterocycl. Compd. – 2010. – Т. 46, № 4. – P. 495–499. http://link.springer.com/article/10.1007/s10593-010-0537-7

47. Pokhodylo N.T., Matiychuk V.S., Obushak M.D. Synthesis of isothiocoumarin derivatives // Chem. Heterocycl. Compd. – 2010. – Т. 46, № 2. – Р. 140-145. http://link.springer.com/article/10.1007/s10593-010-0484-3

48. Matiychuk V.S., Obushak M.D., Lytvyn R.Z., Horak Yu.I. Synthesis of heterocycles on the basis of arylation products of unsaturated compounds. 19. Arylation of 2-acetylthiophene and the synthesis of 2-(5-aryl-2-thien- yl)-4-quinolinecarboxylic acids // Chem. Heterocycl. Compd. – 2010. – Vol. 46, № 1. – P. 50–55. http://link.springer.com/article/10.1007/s10593-010-0468-3

49. Pokhodylo N.T., Matiychuk V.S., Obushak М.D. Сhemoselective reactions of the aryl azides with ethyl 3-oxo-4-(triphenylphosphoranylidene)butanoate // Chem. Heterocycl. Compd. – 2009. – Vol. 45, № 12. – P. 1469–1472. http://link.springer.com/article/10.1007/s10593-010-0452-y

50. Pokhodylo N.T., Savka R.D., Matiichuk V.S., Obushak N.D. A study of alkylation regioselectivity of 5-substituted tetrazoles with chloroacetamides // Russ. J. Gen. Chem. . – 2010. – Т. 80, № 4. – Р. 836–841. http://link.springer.com/article/10.1134/S1070363210040262

51. Pokhodylo N.T., Matiichuk V.S., Obushak N.D. Methyl 3-cyclopropyl-3-oxopropanoate in the synthesis of heterocycles having a cyclopropyl substituent // Russ. J. Org. Chem. . – 2010. – Vol. 46, № 6. – Р. 894-897. http://link.springer.com/article/10.1134/S1070428010060199

52. Pokhodylo N.T., Matiichuk V.S., Obushak N.D. Synthesis and transformations of 1-(azidophenyl)-1H-tetrazoles // Russ. J. Org. Chem. . – 2010. – Т. 46, № 4. – Р. 556–560. http://link.springer.com/article/10.1134/S1070428010040196

53. Pokhodylo N.T., Shiika O.Ya., Matiichuk V.S., Obushak N.D. Synthesis of [5-(1H-1,2,3-triazol-4-yl)-1,3,4-oxadiazol-2-yl]pyridines // Russ. J. Org. Chem. . – 2010. – Т. 46, № 3. – Р. 417–421. http://link.springer.com/article/10.1134/S1070428010030206

54. Martyak R.L., Obushak N.D., Matiіchuk V.S. Synthesis of heterocycles on the basis of arylation products of unsaturated compounds: XX. Reaction of 2-aryl-1,4-benzoquinones with potassium O-butyl carbonodithioate // Russ. J. Org. Chem. . – 2010. – Т. 46, № 3. – P. 394–398. http://link.springer.com/article/10.1134/S1070428010030164

55. Pokhodylo N.T., Obushak N.D. Synthesis of 6-(5-sulfanyl-1H-tetrazol-1-yl)-2H-chromen-2-one and 5-methyl-1-(2-oxo-2H-chromen-6-yl)-1H-1,2,3-triazole-4-carboxylic acid // Russ. J. Org. Chem. – 2010. – Vol. 46, № 11. – Р. 1748–1749. http://link.springer.com/article/10.1134/S1070428010110242

56. Туриця В., Обушак М., Матійчук В. Ізокумарини. Методи синтезу (огляд) // Праці Наукового Товариства ім. Шевченка. Сер. хем. і біохем. – 2010. – Т. 25. – С. 82–110. http://www.irbis-nbuv.gov.ua/cgi-bin/irbis_nbuv/cgiirbis_64.exe?Z21ID=&I21DBN=UJRN&P21DBN=UJRN&S21STN=1&S21REF=10&S21FMT=juu_all&C21COM=S&S21CNR=20&S21P01=0&S21P02=0&S21P03=PREF=&S21COLORTERMS=0&S21STR=pntsh_him

57. Біла Є., Обушак М. Механізм реакції ненасичених сполук з солями арендіазонію. Йон-радикальне приєднання до кратного зв’язку (огляд) // Праці Наукового Товариства ім. Шевченка. Сер. хем. і біохем. – 2010. – Т. 25. – С. 111–141. http://www.irbis-nbuv.gov.ua/cgi-bin/irbis_nbuv/cgiirbis_64.exe?Z21ID=&I21DBN=UJRN&P21DBN=UJRN&S21STN=1&S21REF=10&S21FMT=juu_all&C21COM=S&S21CNR=20&S21P01=0&S21P02=0&S21P03=PREF=&S21COLORTERMS=0&S21STR=pntsh_him

58. Потопник М.А., Матійчук В.С., Обушак М.Д. Синтез та протипухлинна активність похідних піразоло[3,4-d]піридазину // Фарм. журн. – 2009. – № 4. – С.86–89.

59. Потопник М.А., Бондар Н.Є., Обушак М.Д., Матійчук В.С. Синтез і дослідження антиоксидантної дії етил 4-[6-(ариламіно)-4-оксо-5-ціано-3,4-дигідро-2Н-1,3-тіазин-2-іл]-1-феніл-1Н-піразол-3-карбоксилатів // Ukrainica Bioorganica Acta. 2009. – № 2. – С. 42–46. http://www.bioorganica.org.ua/UBAdenovo/pubs_7_2_09/Matyychuk.pdf

60. Потопник М.А., Скробала В.Е., Матійчук В.С., Обушак М.Д. Синтез та протипухлинна активність 2-арил-4-[(гетарилсульфаніл)метил]-3-метил-2,6-дигідро-7Н-піразоло[3,4-d]піридазин-7-онів // Клінічна фармація, фармакотерапія та медична стандартизація – 2009. – № 3–4. – С. 161–165. http://www.irbis-nbuv.gov.ua/cgi-bin/irbis_nbuv/cgiirbis_64.exe?Z21ID=&I21DBN=UJRN&P21DBN=UJRN&S21STN=1&S21REF=10&S21FMT=JUU_all&C21COM=S&S21CNR=20&S21P01=0&S21P02=0&S21P03=IJ=&S21COLORTERMS=1&S21STR=%D0%9673756

61. Туриця В.В., Матійчук В.С., Обушак М.Д., Нефедов Є.А. Прогноз біологічної активності та синтез амідів 3-метил-3,4-дигідроізокумарин-3-карбонової кислоти // Клінічна фармація, фармакотерапія та медична стандартизація – 2009. – № 3–4. – С. 156–160. http://www.irbis-nbuv.gov.ua/cgi-bin/irbis_nbuv/cgiirbis_64.exe?Z21ID=&I21DBN=UJRN&P21DBN=UJRN&S21STN=1&S21REF=10&S21FMT=JUU_all&C21COM=S&S21CNR=20&S21P01=0&S21P02=0&S21P03=IJ=&S21COLORTERMS=1&S21STR=%D0%9673756

62. Obushak M.D., Matiychuk V.S., Turytsya V.V. A new approach to the synthesis of 3,4-dihydroisocoumarin derivatives // Tetrahedron Lett. – 2009. – Vol. 50, № 45. – P. 6112–6115. http://www.sciencedirect.com/science/article/pii/S0040403909015767

63. Pokhodylo N.T., Matiychuk V.S., Obushak M.D. Synthesis of ethyl 4,5-disubstituted 2-azido-3-thiophenecarboxylates and use in the synthesis of thieno [3,2-e][1,2,3]triazolo[1,5-a]pyrimidin-5(4H)-ones // Tetrahedron – 2009. – Vol. 65, № 13 – Р. 2678–2683. http://www.sciencedirect.com/science/article/pii/S0040402009001318

64. Pokhodylo N.T., Matiychuk V.S., Obushak M.D. One-pot multicomponent synthesis of 1-aryl-5-methyl-N-R2-1H-1,2,3-triazole-4-carboxamides: An easy procedure for combinatorial chemistry // J. Comb. Chem. – 2009. – Vol. 11, № 3. – Р. 481–485. http://pubs.acs.org/doi/abs/10.1021/cc900012w

65. Pokhodylo N. T., Matiychuk V. S., Obushak M. D. Synthesis of Triazoles via Regioselective Reactions of Aryl Azides with Cyanoacetyl Pyrroles and Indoles // Synthesis. – 2009. – No. 8 – P. 1297–1300. https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0028-1087992

66. Pokhodylo N.T., Teslenko Y.O., Matiychuk V.S., Obushak M.D. Synthesis of 2,1-benzisoxazoles by nucleophilic substitution of hydrogen in nitroarenes activated by the azole ring // Synthesis. – 2009. – № 16. – Р. 2741–2748. https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0029-1216875

67. Pokhodylo N.T., Matiychuk V.S., Obushak M.D. (Arylsulfonyl)acetones and -acetonitriles: new activated methylenic building blocks for synthesis of 1,2,3-triazoles // Synthesis. – 2009. – № 14 – P. 2321–2323. https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0029-1216850

68. Pokhodylo N.T., Matiychuk V.S., Obushak M.D. Regioselective cycloaddition route to 5-aminotriazole // Synfacts – 2009. – № 7. – P. 723. https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0029-1217316

69. Gorak Yu.I., Obushak N.D., Matiichuk V.S., Lytvyn R.Z. Synthesis of heterocycles from arylation products of unsaturated compounds: XVIII. 5-Arylfuran-2-carboxylic acids and their application in the synthesis of 1,2,4-thiadiazole, 1,3,4-oxadiazole, and [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives // Russ. J. Org. Chem. – 2009. – Vol. 45, № 4. – P. 541–550. http://link.springer.com/article/10.1134/S1070428009040125

70. Matiichuk V.S., Potopnyk M.A., Obushak N.D. Synthesis and reactions of 3-(3-ethoxycarbonyl-1-phenyl-1H-pyrazol-4-yl)propenic acid // Russ. J. Org. Chem. – 2009. – Vol. 45, № 5. – P. 712–718. http://link.springer.com/article/10.1134/S107042800905011X

71. Obushak N.D., Lesyuk А.I., Gorak Yu.I., Matiichuk V.S. Mechanizm of Meerwein arylation of furan derivatives // Russ. J. Org. Chem. – 2009. – Vol. 45, № 9. – P. 1375–1381. http://link.springer.com/article/10.1134/S1070428009090103

72. Obushak N.D., Gorak Yu.I., Matiichuk V.S., Lytvyn R.Z. Synthesis of heterocycles based on arylation products of unsaturated compounds: XVII. Arylation of 2-acetylfuran and synthesis of 3-R-6-(5-aryl-2-furyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines // Russ. J. Org. Chem. – 2008. – Vol. 44, № 11. – P. 1689–1694. http://link.springer.com/article/10.1134/S1070428008110213

73. Pokhodylo N.T., Savka R.D., Matiichuk V.S., Obushak N.D. Synthesis and Selected Transformations of 1-(5-methyl-1-aryl-1H-1,2,3-triazol-4-yl)ethanones and 1-[4-(4-R-5-methyl-1Н-1,2,3-triazol-1-yl)phenyl]ethanones // Russ J. Gen. Chem. – 2009. – Vol. 79, № 2. – Р. 309–314. http://link.springer.com/article/10.1134/S1070363209020248

74. Pokhodylo N.T., Matiychuk V.S., Obushak N.D. A convenient method for the synthesis of thiopyrano[4,3-c]quinoline, a new heterocyclic system // Chem. Heterocycl. Compds. – 2009. – Vol. 45, № 1. – P. 121–122. http://link.springer.com/article/10.1007/s10593-009-0238-2

75. Pokhodylo N.T., Matiychuk V.S., Obushak M.D.. Synthesis of [1,2,3]triazolo-[4′,5′:4,5]pyrimido[1,6-a]benzimidazole, a new heterocyclic system // Chem. Heterocycl. Compds. – 2009. – Vol. 45, № 2. – P. 245–247. http://link.springer.com/article/10.1007/s10593-009-0255-1

76. Pokhodylo N.T., Matiychuk V.S., Obushak M.D. Synthesis of the 1H-1,2,3-triazole derivatives by the cyclization of arylazides with 1-(1,3-benzothiazol-2-yl)acetone, 1,3-benzothiazol-2-ylacetonitrile and (4-aryl-1,3-thiazol-2-yl)acetonitrile // Chem. Heterocycl. Compds. – 2009. – Vol. 45, № 4. – P. 483–488. http://link.springer.com/article/10.1007/s10593-009-0287-6

77. Pokhodylo N.T., Matiychuk V.S., Obushak M.D. Synthesis of the new heterocyclic system – pyrido[3′,2′:4,5]thieno[2,3-e]-[1,2,3]triazolo[1,5-a]pyrimidine // Chem. Heterocycl. Compds. – 2009. – Vol. 45, № 7. – P. 1100–1102. http://link.springer.com/article/10.1007/s10593-009-0338-z

Biography

M. Obushak was born in Myshyn, Ivano-Frankivs’k region.
1977 р. – МS in chemistry (Chernivtsi University, Ukraine)
1977–78 – engineer on the Glassplastics works (Severodonetsk, Lugansk region)
Since 1978 he work on department of organic chemistry Ivan Franko National University of Lviv (Ukraine).
1978–81 – postgraguate student
1981–92 – head of research laboratory
1983 – Ph.D. Degree in chemistry
1986–87 – Post-Doctoral Research under the leadership professor H. G. O. Becker (Technische Hochschule, Merseburg, Germany)
1992–2000 – docent (associate professor) of organic chemistry department
1999 – D.Sc. Degree in chemistry
2000–03 – professor of organic chemistry department
since 2003 – head of organic chemistry department

M. Obushak has published about 400 papers, 43 patents and 11 textbooks
Member of the Taras Shevchenko scientific society (since 1992).
Member of the editorial board of four scientific journals.

Awards

Honored Professor of Ivan Franko National University of Lviv – 2013.
In 1995 he has been honorary title “Soros Associate Professor” (ISSEP).

Schedule

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